Enable JavaScript to run this app.
Skip to main content
OpenTable logo
  1. Home
  2. United States
  3. San Diego

Best American Restaurants in Mission Valley

Price
Regions
Neighborhoods
Top Rated
Dining Options
Seating Options
Award-winning
Accessibility

149 restaurants available nearby

How are Featured results ranked

A photo of Gravity Heights Mission Valley restaurant
4.8
Exceptional(305)
Price: Moderate
• American • Mission Valley
Booked 12 times today
Gravity Heights Mission Valley offers an exceptional Californian cuisine experience that perfectly marries the vibrant San Diego beer scene with a stellar dining experience. Located in the heart of Mission Valley, this spacious brewpub is known for its "delicious food, exceptional service, and genuine hospitality." The expansive outdoor beer garden and inviting ambiance make it a perfect spot to enjoy the Californian flavors that diners rave about. Reviews highlight the "amazing place and food," with standout dishes like the "Golden Mustard Chicken wings" and the "Tikka Masala pot pie." It's a must-visit for anyone looking to savor authentic Californian cuisine.
A photo of King's Fish House - Mission Valley restaurant
4.6
Exceptional(2316)
Price: Moderate
• American • Mission Valley
Booked 16 times today
King's Fish House in Mission Valley, San Diego, is a sublime haven for American seafood enthusiasts, proudly offering a "consistently good" experience that diners rave about. This family-run establishment, with its roots deeply embedded in American culinary tradition, is famed for its fresh, daily-changing menu that includes everything from oysters to creatively prepared fish dishes. "Phenomenal service and great food," echo patrons who admire the attentive staff and the inviting atmosphere that caters to both casual gatherings and special occasions. With its irresistible offerings like the "generationally delicious" sourdough bread, King's Fish House is a must-visit for those craving authentic American seafood.
A photo of Starlite restaurant
4.7
Exceptional(283)
Price: Expensive
• American • Mission Hills
Booked 86 times today
Starlite: A timeless San Diego icon with a fresh future, helmed by Chef Ted Smith.Please note: Our establishment is 21+
A photo of Quixote restaurant
4.7
Exceptional(1237)
Price: Moderate
• American • North Park
Booked 45 times today
Quixote in North Park, San Diego is a culinary gem that beautifully captures the essence of American cuisine with a delightful twist. Known for its "amazing food" and "incredible service," Quixote offers a menu filled with creative and exciting dishes that push the boundaries of traditional American flavors. Diners rave about the "best guacamole ever" and the must-try "crab corn donut," highlighting the restaurant's innovative approach. The "impeccable ambiance" and "warm atmosphere" create a memorable dining experience, perfect for any occasion. Quixote's dedication to quality and authenticity makes it a standout choice for anyone seeking a unique American dining adventure.
A photo of Great Maple San Diego restaurant
4.8
Exceptional(4560)
Price: Moderate
• American • Hillcrest
Booked 107 times today
Great Maple San Diego, nestled in the vibrant neighborhood of Hillcrest, is a beacon of excellence in Contemporary American cuisine. This modern eatery is celebrated for its "outstanding" food and "exceptional" service, making it a favorite destination for brunch, lunch, and dinner. Diners rave about the delightful maple bacon donuts and "delectable" brisket hash, highlighting the creative use of fresh, local ingredients. Reviewers consistently praise the "huge portions" and "fantastic flavors," ensuring no one leaves hungry. With its inviting atmosphere and "friendly" staff, Great Maple offers a truly authentic and memorable dining experience that captures the essence of Contemporary American cuisine.
A photo of ARLO San Diego restaurant
4.4
Awesome(843)
Price: Moderate
• American • Mission Valley
Booked 21 times today
ARLO San Diego in Mission Valley is a seafood lover's paradise, offering an authentic and exquisite dining experience. With dishes crafted from fresh, local ingredients, ARLO stands out as a beacon of quality Seafood cuisine. Diners rave about the "tender and packed with flavor" octopus and the "perfectly cooked and seasoned" Pan Roasted Seabass, praising the melt-in-your-mouth quality of the seafood. The restaurant's vibrant atmosphere, coupled with a sweeping patio and inventive cocktails, makes it a must-visit destination. ARLO's accolades, including Best Hotel Restaurant in San Diego Magazine's Best of 2024, further attest to its exceptional seafood offerings.
A photo of Blanco Cocina + Cantina – Fashion Valley restaurant
4.8
Exceptional(581)
Price: Moderate
• American • Mission Valley
Booked 10 times today
Blanco Cocina + Cantina – Fashion Valley is a standout destination in Mission Valley, San Diego for those seeking an exceptional cocktail bar experience. Known for its vibrant atmosphere and refreshing drinks, Blanco’s cocktail bar is a "perfect spot for sipping margaritas," as delighted patrons often rave. The spicy skinny margaritas are a particular highlight, earning consistent praise for their bold flavors and delightful presentation. With an inviting outdoor area featuring comfortable seating and heat lamps, it’s an ideal place to unwind. Whether you're enjoying a casual hangout or celebrating a special occasion, Blanco ensures your cocktail experience is nothing short of extraordinary.
A photo of True Food Kitchen - San Diego FV restaurant
4.6
Exceptional(1986)
Price: Moderate
• American • Mission Valley
Booked 18 times today
True Food Kitchen in San Diego is a haven for those seeking high-quality Vegetarian and Vegan cuisine. Located in the vibrant Fashion Valley area, this chef-driven restaurant is celebrated for its "delicious and fresh" vegetarian dishes that are both nutrient-dense and full of flavor. Diners rave about standout dishes like the spaghetti squash casserole, which is described as "rich, flavorful, and perfectly seasoned," and the butternut squash pizza, praised for its "unique and delicious take on pizza." With an "inviting atmosphere" and attentive service, True Food Kitchen promises an exceptional dining experience that combines health and indulgence seamlessly.
A photo of Herb & Wood restaurant
4.7
Exceptional(6755)
Price: Expensive
• American • Little Italy
Booked 40 times today
Herb & Wood in San Diego's vibrant Little Italy is a shining example of exquisite American cuisine. Celebrated Chef Brian Malarkey crafts a menu that elevates rustic, wood-fired dishes, blending Mediterranean flair with California's commitment to seasonality and sustainability. Diners rave about the "incredible dinner" experience, showcasing "amazing, flavorful food" and "outstanding service." The ambiance is described as "beautiful" and "welcoming," making every visit memorable. Signature dishes like the pork belly and filet mignon are praised for their exceptional taste. Whether you're celebrating a special occasion or enjoying a night out, Herb & Wood promises a "truly memorable culinary experience."
A photo of Trust Restaurant restaurant
4.8
Exceptional(1209)
Price: Expensive
• American • North Park
Booked 53 times today
We’re a neighborhood restaurant, at our heart. A place for our community to gather, to celebrate, to raise yet another glass in a toast to good tidings. We believe in bold flavors, cooked simply over an open flame. We believe in seasonality, in forging relationships with local farmers, makers, and purveyors to bring you the bounty this fine city has to offer. We believe in the power of wine and cocktails to elevate your meal, to create an experience that, when paired with superior service, creates something completely unique, forging a bond of trust, one would say, between you and us. These four walls were meant for you. Welcome.

How is content generated

See what locals rave about

From verified diners like you
From verified diners like you

Discover best American restaurants in Mission Valley

Discover the rich flavors of American cuisine in Mission Valley, San Diego, where a diverse array of restaurants serves up everything from classic dishes to innovative culinary twists. Mission Valley's dining scene is vibrant and eclectic, offering a taste of America's culinary diversity, with options ranging from seafood specialties to expertly crafted American classics. Each restaurant in this area brings its own unique flair to American dining, emphasizing fresh, local ingredients and creative preparation techniques. Whether you're craving a hearty breakfast, a sumptuous dinner, or a delightful dessert, you'll find establishments catering to a variety of tastes and dietary needs. The ambiance in these eateries ranges from casual and family-friendly to more sophisticated dining experiences, ensuring a setting for any occasion. With their commitment to quality and service, Mission Valley's American cuisine restaurants promise a satisfying dining experience that resonates with both locals and visitors alike.

OpenTable
  • About Us
  • Blog
  • Careers
  • Press
More
Businesses
  • Restaurant Management Solutions
  • Restaurant Reservation Software
  • Restaurant Marketing Software
  • Restaurant Event Software
  • OpenTable For Restaurants
  • OpenTable For Restaurant Groups
  • Restaurant Resources
  • OpenTable Pricing & Plans
Join us on
  • Privacy Policy
  • Terms of Use
  • Cookies and Interest-Based Ads
  • Do Not Sell or Share My Personal Information
  • Cookie Preferences
Copyright © 2025 OpenTable, Inc. 1 Montgomery St Ste 500, San Francisco CA 94104 - All rights reserved.
OpenTable is part of Booking Holdings, the world leader in online travel and related services.
Booking Logo
Priceline Logo
KAYAK Logo
Agoda Logo
OpenTable Logo