Diners' Choice: American restaurants in Mississippi

OpenTable

Updated April 05, 2025

Looking for restaurants with the best overall American cuisine in Mississippi? You’re in the right place. Each month OpenTable analyzes more than 400,000 new diner reviews. We sort the results by category to help you discover new favorites. It's a great partnership: you reserve, eat, and review. We listen...and deliver the results for all to benefit. Enjoy!

Restaurant Anchuca

4.9

4.9 (62)

$31 to $50

American

Vicksburg

About the restaurant

Nestled within Vicksburg’s oldest neighborhood, & located inside the town’s oldest columned mansion/bed & breakfast that survived the Civil War, Restaurant Anchuca exudes true Southern hospitality & happiness — after all, the name “Anchuca” is derived from the Choctaw word meaning “happy home.”

Don’t miss the filet — it’s so tender you won’t need a steak knife! Guests consistently say it’s the best filet they’ve ever had. Other specialties include the scrumptious shrimp & grits, paneed catfish featuring Mississippi farm-raised catfish, exceptional chicken piccata, & a variety of dinner and dessert specials.

Looking for great wine? With an emphasis on family-owned vineyards, artisan producers, highly sought after imports, & a wide range of price points, Restaurant Anchuca is proud to deliver world-class wine alongside Mississippi’s world-class hospitality. Our award-winning selection has been curated especially for Restaurant Anchuca by Mississippi’s only advanced-level sommelier.

Top review

PixieVIP

Dined on Apr 14, 2025

What a gem! Anchuca means "happy Home" in Choctaw, and we certainly found that to be true. We were celebrating our anniversary and could not have picked a better place. Kerri was fantastic as she was very fun and friendly. The food was excellent ad the atmosphere impeccable. If you want a lovely, quiet, romantic evening, this is the place. It was perfect.

McEwens - Oxford

4.8

4.8 (1212)

$30 and under

American

Oxford

About the restaurant

McEwen's Oxford is passionate about food, wine, and you! We strive to create a place you long to come back to again and again. With an eclectic blend of styles, McEwen's Oxford emphasizes Southern food that is raised to new and unusual heights. Lunch offers a wide array of excellent sandwiches, salads and business entrees, while dinner leans toward the more elaborate and inventive. Our commitment to a relaxed atmosphere and charming personality has McEwen's destined to become one of Oxford's most popular destinations. We boast on employing a knowledgeable and attentive staff that is always ready to serve our guests. In addition to the bar and dining room, a private room is available for parties up to 25 people.

Top review

Cynthia

Dined 6 days ago

Food was great and they accommodated us in every way! Always a classic for us!

Discover more

4.8

4.8 (427)

$30 and under

American

Ocean Springs

About the restaurant

* Voted BEST DATE NIGHT SPOT
*We are lively and energetic! Opt for outdoors for a quieter experience!
*Reservations required for dinner only.
* Parties of 12 guests or larger are only done via phone.
*Lunch reservations for groups of 6 or more only.

Maison de Lu was started in Ocean Springs in 2008. A small sandwich shop evolved into a town staple! Offering different menus for lunch and dinner allows appeal to anyone! We offer a beautiful courtyard dining experience (with heaters), a full service bar, and a lively indoor dining. Whether it's date night with that special someone or girl's night, we've got you covered!

Our lunch menu features unique salads, creative sandwiches, and fresh local seafood. Our dinner menu opens up to anything from steak to seafood! We are known for fresh fish, and specialty meats such as our New Zealand Lamb, veal chop, and brined pork chop! We encourage people to "get outside the box" when dining with us!

Top review

Kevin

Dined on Apr 19, 2025

Celebrated anniversary…sat outside, great atmosphere, great food, great service.

Discover more

4.7

4.7 (527)

$31 to $50

American

Tupelo

About the restaurant

Recently named the Best Fining Dining Restaurant in Mississippi by Mississippi Magazine and located in the Fairpark District, Park Heights offers Chef Thomas Lester's menu including seared hanger steak, yellowfin tuna tartar, heirloom tomato caprese, prosciutto wrapped monkfish and prime cuts of beef. The main dining room, with its reclaimed hardwood floors and retro lighting, provides an atmosphere that is sophisticated without feeling formal. Often sited as the best in town, the service is professional and gracious, and the wine list is extensive. If you enjoy dining al fresco, try the rooftop or patio which have amazing views of downtown.

Top review

Bill

Dined on Apr 22, 2025

Park Heights is our place to go when we want to really enjoy our dinner. Maine Sole and the Filet were spot on. Service was perfect. Great dining experience.

Discover more

Popular dish

Miso BBQ Salmon

Restaurant 1818 at Monmouth Historic Inn & Gardens

4.7

4.7 (452)

$31 to $50

American

Natchez

About the restaurant

At Restaurant 1818 you will dine in what was originally the Men's and Ladies’ Parlors of the Main House. These two parlors are adorned with authentic period crystal gasoliers. These impressive reproduction chandeliers and wall sconces were custom made for Monmouth by the artisans at Waterford Crystal in Ireland.

Guests have complete dining freedom when they reserve a table at Restaurant 1818. Here guests can select menu items on an a la carte basis from the gourmet appetizers, soups, salads, entrees, and desserts offered that evening. A full wine list and wine by the glass program is available to ensure your dining experience is the very best Natchez has to offer!

Private dining by candlelight is also offered for 8 to 12 people at the main dining room table. This room exemplifies the elegant dining experience which has been customary since the days of John and Eliza Quitman.

Top review

David/Charlotte

Dined on Apr 14, 2025

As usual, the food was phenomenal. We actually dined with you on two consecutive nights and can give you accolades for both nights. The steaks were unbelievably tender and cooked to perfection. On the second night, the pork chops, greens and sweet potatoes with superb. There was no room for desserts, but I’m sure they were excellent. George was our waiter and he was very attentive, courteous & beyond helpful. It is comforting to know that when you accidentally leave your credit card at the restaurant, you will receive a phone call before you can reach your next destination. I am thankful that OpenTable had my telephone number and the restaurant could give us a call.

Patio 44- Biloxi

4.4

4.4 (794)

$30 and under

American

Biloxi

About the restaurant

Patio 44 opened their gates to the Pine Belt in September 2013, and expanded to the Mississippi Gulf Coast in November 2016, offering an experience like no other. Our beautiful patio-themed restaurant not only provides the area with a beautiful 50 seat patio, but also a very elegant indoor dining area and private area. Patio 44 offers a Chef-driven menu that uses only the finest ingredients possible, a wine list that offers more than 100 bottles from across the world, and one-of-a-kind Hand Crafted Cocktails. Come see what we have to offer. Casual dining at its best!

Top review

Renee

Dined 5 days ago

We had a great experience at Patio 44. We had the crab cakes and the redfish on Half-shell. Everything was cooked to perfection. I loved the Brussels sprouts as well!! The Waitress was new and very attentive and helpful. The owner came around and checked on everyone. We dined outside. Loved the fire/water feature.

One Thirty One Lameuse

4.4

4.4 (238)

$31 to $50

American

Biloxi

About the restaurant

Welcome to One Thirty One Lameuse, the newest restaurant in downtown Biloxi! We invite you to explore and be inspired by our restaurant while allowing us to help you host your perfect event. We are open Wednesday - Sunday.

Top review

Joseph

Dined on Apr 21, 2025

Michael was absolutely amazing! Food was delicious and drinks were as well!

Patio 44

4.5

4.5 (217)

$30 and under

American

Hattiesburg

About the restaurant

A unique patio style restaurant in the Hub City with delicious food, tasty cocktails and comfortable atmosphere. Patio 44 features creole cuisine and an extensive wine and premium spirits list.

Top review

Larry

Dined on Apr 20, 2025

Our waiter, Dexter, was wonderful. We enjoyed our seating out on the patio. Food was delicious.

Rebecca's

4.5

4.5 (77)

$30 and under

American

Flowood

About the restaurant

Welcome to Rebecca's!

Top review

Alana

Dined on Apr 1, 2025

Food and service was excellent although the food is a little expensive as well as the drinks but it was date night for me and my husband so it was worth it. That’s some place. We would go weekly but possibly once a month or every other month.

Hard Rock Cafe - Biloxi

4.5

4.5 (518)

$30 and under

American

Biloxi

About the restaurant

Hard Rock Cafe is a global phenomenon with 185 cafes that are visited by nearly 80 million guests each year. The first Hard Rock Cafe opened on June 14, 1971, in London, England, and from there the brand has expanded to major cities and exotic locations around the world.

Top review

DebVIP

Dined 1 day ago

Everything was great Our server Jana was exceptional and very attentive.

Discover more

Experience

Fresh Beats

Experience

Flavors that Fiesta - Spice up your Cinco de Mayo!

Experience

Get Your Party On! Spend Party Hour With Us!

Explore Diners' Choice best of Mississippi