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Sassafras Southern Bistro, Greenville, SC

Sassafras Southern Bistro

4.8 (3613)
$30 and under
Southern
103 N Main St #107, Greenville, SC 29601

Make a reservation

2 people
7:00 PM
Booked 44 times today

About this restaurant

  • Good for special occasions
  • Charming
  • Neighborhood gem
Located in the heart of downtown Greenville, South Carolina, Sassafras Southern Bistro serves an eclectic menu of American cuisine with a truly Southern influence. Menu items include steak, fresh seafood, salads, and amazing desserts. Sassafras Southern Bistro has a full bar featuring local beers on tap and an extensive wine selection both by the glass and by the bottle.



Start out your meal at Sassafras Southern Bistro with one of their amazing appetizers like the spicy pork tenderloin or the famous blue crab and pepper-jack nachos. Choose from entrees like the raved about shrimp and grits or the filet with house made pimento. Some vegetarian and gluten free options are available upon request.

Additional information

  • Dining style
    Casual Dining
  • Price
    $30 and under
  • Cuisines
    Southern, American
  • Hours of operation
    Mon–Thu 5:00 pm–9:00 pm Fri 5:00 pm–9:30 pm Sat 4:30 pm–9:30 pm
  • Phone number
  • Payment options
    AMEX, Discover, Mastercard, Visa
  • Dress code
    Casual Dress
  • Neighborhood
    Greenville
  • Cross street
    Main Street and Coffee Street
  • Parking details
    Parking is available in the Richardson Street parking garage that is conveniently located just a few steps away and is free to park on the weekends!
  • Public transit
    Parking garage is located at 66 Richardson Street. Once you park your car walk out of the parking garage and walk right into the open area. You will see Sassafras here, we have the green awning!
  • Additional
    Bar/Lounge, Beer, BYO Wine, Cocktails, Corkage Fee, Full Bar, Gluten-free Options, Happy Hour, Non-Smoking, Patio/Outdoor Dining, Patio/Outdoor Dining, Private Room, Wheelchair Access, Wine

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What 3,613 people are saying

Sassafras Southern Bistro reviews from people who’ve dined at this restaurant. Based on recent rating.

Overall ratings and reviews

Reviews can only be made by diners who have eaten at this restaurant

4.8
4.8 based on recent ratings
  • 4.8Food
  • 4.9Service
  • 4.7Ambience
  • 4.7Value

NoiseModerate

Loved For

  • South Carolina

    Best Value

  • South Carolina

    Southern

  • Greenville

    Best Overall

  • Greenville

    Best Food

  • Greenville

    Best Service

  • Greenville

    Best Ambiance

  • Greenville

    Best Value

  • Greenville

    Good for groups

  • Greenville

    Great for outdoor dining

Review summary

AI-generated from verified diner reviews
Sassafras Southern Bistro delights with "fantastic waiter, great food" and a "wonderful atmosphere." Known for its Southern charm, the restaurant offers "amazing food" like shrimp and grits, and "attentive service." Frequent diners praise the "generous portions" and "reasonable prices." Perfect for special occasions, it's a local favorite.
3,613 Reviews
  1. Wayne

    South Carolina19 reviews

    5.0

    Dined 2 days ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 4
    My wife and I dined there for our anniversary, and we had a wonderful experience. The food, the service, environment was very pleasant.

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  2. Matthew VIP

    Pittsburgh / Western PA38 reviews

    5.0

    Dined 4 days ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    What a great southern restaurant experience. Our server was incredible, and really knew how to make patrons feel at home. The food and drinks were all excellent, and the prices for everything (including drinks) were so reasonable, it was refreshing. This truly is a gem of a restaurant.

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  3. Patty

    South Carolina6 reviews

    5.0

    Dined 4 days ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Excellent place to enjoy an evening of good food at a great price.

    Is this helpful?

  4. Susan

    South Carolina7 reviews

    5.0

    Dined 5 days ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    We love Sassafras! Delicious food, great cocktails, and wonderful service. I love the location which has a wonderful vibe. Highly recommend.

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  5. Chad

    South Carolina4 reviews

    5.0

    Dined 5 days ago

    1. Overall 5
    2. Food 5
    3. Service 4
    4. Ambience 5
    Sassafras Bistro was quite nice from the very beginning as we were seated promptly and made to feel very welcome. We were shown to a quiet, comfortable table in the back and found the ambiance of the place to be pleasant and well thought through. We were content with the temperature, surroundings, decor, and noise level. I chose this restaurant specifically looking for a good risotto and sea scallops dish and I was not disappointed at all. After starting with the cold tuna appetizer, I happily got what I came for and the risotto was perfectly seasoned and creamy. It was topped with 6 good-sized whole sea scallops seared to perfection with nicely sauteed spinach in the middle. There was no need for additional seasoning at all. It was a large portion for sure and I definitely could see myself returning just for this dish again. My wife had the crab cakes and seemed just as satisfied with her choice. It is obvious that someone has put a lot of attention to detail into this little restaurant and I am very happy that they did! I look forward to my next visit.

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  6. Mary

    South Carolina8 reviews

    5.0

    Dined 5 days ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    What a delightful restaurant! We loved the brick walls and the art displayed. We were greeted by the manager and host on arrival and seated shortly after. Service was excellent. We shared southern fried chicken, a shrimp appetizer, along with green beans, mashed potatoes and collards. All dishes were so tasty! The two of us carried home leftovers- I didn’t see any other patrons without a leftover bag-portions were generous! Wish we had not been too full for dessert! We will return soon!

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  7. Debbie

    Atlanta9 reviews

    5.0

    Dined 7 days ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    We were visiting from out of town and looked up the restaurant the reviews were spot on! Food was absolutely amazing and our waitress was very attentive to us. It was half price wine night. We had a 5 star meal all for $100. We will be back when we visit the area again. Debbie

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  8. Liz

    South Carolina1 review

    5.0

    Dined 7 days ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    I have Celiac Disease and when we were given our menus when we sat down, there was a full GF menu that was brought in addition to the regular menu. It was sincerely appreciated! Great food, great service - can't wait to come back. Thank you!

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  9. Kenneth

    Jacksonville / Northeast Florida5 reviews

    5.0

    Dined on June 17, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Great food and service. They have a separate gluten free menu with plenty of options.

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  10. Elizabeth

    South Carolina1 review

    5.0

    Dined on June 17, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Dining at Sassafras Southern Bistro was an absolute treat! From the moment we arrived, the ambiance struck the perfect balance between elegant and welcoming. The cozy, Southern-inspired decor created a charming atmosphere that made us feel instantly relaxed. The menu is a celebration of Southern flavors with a modern twist. I ordered the Crab Cakes, and it was nothing short of spectacular—rich in flavor, beautifully plated, and cooked to perfection. Every element felt thoughtfully prepared, and the freshness of the ingredients truly shone through. What made the evening even more memorable was the exceptional service. Our server was attentive, knowledgeable, and genuinely friendly, offering helpful suggestions without ever feeling overbearing. You can tell the staff takes real pride in creating a memorable dining experience. Whether you’re a local or just passing through, Sassafras Southern Bistro is the kind of place you’ll want to return to again and again. Delicious food, warm hospitality, and a lovely setting—what more could you ask for? Highly recommended!

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FAQs

Sassafras Southern Bistro is rated 4.8 stars by 3613 OpenTable diners.

Yes, you can generally book this restaurant by choosing the date, time and party size on OpenTable.

  1. Home
  2. United States
  3. South Carolina
  4. Greenville
  5. Greenville

Make a reservation

2 people
7:00 PM
Booked 44 times today
Google Map for Sassafras Southern Bistro

103 N Main St #107, Greenville, SC 29601

Additional information

  • Cross street
    Main Street and Coffee Street
  • Neighborhood
    Greenville
  • Hours of operation
    Mon–Thu 5:00 pm–9:00 pm Fri 5:00 pm–9:30 pm Sat 4:30 pm–9:30 pm
  • Price
    $30 and under
  • Cuisines
    Southern, American
  • Dining style
    Casual Dining
  • Dress code
    Casual Dress
  • Parking details
    Parking is available in the Richardson Street parking garage that is conveniently located just a few steps away and is free to park on the weekends!
  • Public transit
    Parking garage is located at 66 Richardson Street. Once you park your car walk out of the parking garage and walk right into the open area. You will see Sassafras here, we have the green awning!
  • Payment options
    AMEX, Discover, Mastercard, Visa
  • Additional
    Bar/Lounge, Beer, BYO Wine, Cocktails, Corkage Fee, Full Bar, Gluten-free Options, Happy Hour, Non-Smoking, Patio/Outdoor Dining, Patio/Outdoor Dining, Private Room, Wheelchair Access, Wine
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