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Best Southwest American Restaurants in Medical Center

Discover the best restaurants in Medical Center

Explore must-try spots, new openings, and hidden gems.

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4 restaurants available nearby

How are Featured results ranked

A photo of 1 Watson restaurant
4.4
Awesome(519)
Price: Moderate
• Southwest • Downtown
Booked 23 times today
Escape the ordinary at 1 Watson, a rooftop oasis 15 floors above San Antonio. Enjoy stunning views of the River Walk, Main Plaza, and San Fernando Cathedral while indulging in modern Southwestern cuisine and expertly crafted cocktails. Savor Texas-inspired dishes like smoked brisket tacos, fajita shrimp and grits, and tempting tostadas, each reflecting the region's culinary heritage with a contemporary twist. Quench your thirst with a curated selection of craft cocktails. Enjoy refreshing margaritas, the smoky notes of Texas-made bourbon, or vibrant handcrafted gin and tonics. Each drink is designed to enhance the breathtaking views and delicious food. Step into a sophisticated ambiance with industrial-chic design and modern Texas touches. Relax in plush seating and bask in the warm glow of the fire, making 1 Watson the perfect destination for an unforgettable dining experience.
A photo of Sustenio - Eilan Hotel restaurant
3.3
Good(698)
Price: Moderate
• Southwest • La Cantera
Enjoy the diverse flavors of South Texas at Sustenio! Local fresh produce and proteins brought in daily; with influences from Traditional Mexico, Creole and Southern Comfort foods.
A photo of Oro at The Emily Morgan Hotel– a DoubleTree by Hilton restaurant
3.5
Very Good(184)
Price: Moderate
• Southwest • Downtown
Oro Restaurant & Bar combines comfort and class in the heart of downtown San Antonio. Located in the historic Emily Morgan Hotel - A DoubleTree by Hilton, Oro Restaurant has presented a creative and exciting approach to traditional southwestern flavors since 2007. With our modern interior décor, award-winning margaritas, and rotating seasonal menus that showcase the finest local ingredients, we create an upscale dining atmosphere that welcomes locals and visitors alike.
A photo of Tributary S.A. restaurant
3.6
Very Good(33)
Price: Moderate
• Southwest • Downtown
Gracious Hospitality meets Southern Texas Cuisine in a Spirited Scene....At Tributary, we strive to curate a one of a kind guest experience that focuses on catering to our guests’ every need without being pretentious or overbearing. While casual in nature, our restaurant focuses on the intimate details of the dining experience to ensure that our guests are receiving the southern hospitality that they have come to expect from San Antonio.We are dedicated to paying tribute to Texas by crafting an experience inspired by the local farmers who grow our produce, the purveyors who supply us with sustainable seafood and fresh meats, and the artisans who craft the product and curate the experience.

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