Best Southern American Restaurants in Little Italy

Price

$$
$$$
$$$$

Regions

East CountySan Diego

Neighborhoods

Banker's HillBarrio LoganBay ParkChula Vista / BonitaCollege AreaCoronado

Top Rated

CharmingDog-friendlyFancyGood for business mealsGood for groupsGood for special occasions

Dining Options

All dining options

Delivery only

Takeout only

Seating Options

BarCounterStandardHigh TopOutdoor

Award-winning

MICHELIN

Accessibility

Wheelchair access

137 restaurants available nearby

How are Featured results ranked

1. Herb & Wood

4.7

Exceptional(6707)

$$$$Price: Expensive

• Southern american • Little Italy

Booked 67 times today

Herb & Wood in San Diego's vibrant Little Italy is a shining example of exquisite American cuisine. Celebrated Chef Brian Malarkey crafts a menu that elevates rustic, wood-fired dishes, blending Mediterranean flair with California's commitment to seasonality and sustainability. Diners rave about the "incredible dinner" experience, showcasing "amazing, flavorful food" and "outstanding service." The ambiance is described as "beautiful" and "welcoming," making every visit memorable. Signature dishes like the pork belly and filet mignon are praised for their exceptional taste. Whether you're celebrating a special occasion or enjoying a night out, Herb & Wood promises a "truly memorable culinary experience."

2. Kettner Exchange

4.7

Exceptional(1473)

$$$$Price: Expensive

• Southern american • Little Italy

Booked 44 times today

Kettner Exchange in Little Italy, San Diego, offers an exceptional Asian fusion experience that is both inventive and authentic. Executive Chef Brian Redzikowski’s creations have earned the restaurant a coveted spot on the Michelin Guide's Bib Gourmand list since 2019, showcasing high-quality meals at accessible prices. Diners rave about the "spicy garlic noodles" and "juicy cheeseburger special," underscoring the delightful fusion of flavors. The rooftop patio with stunning harbor views enhances the dining ambiance, making it perfect for any occasion. Guests frequently praise the "stellar service" and "amazing cocktails," solidifying Kettner Exchange as a must-visit destination for Asian cuisine enthusiasts.

A photo of Ironside Fish & Oyster restaurant

3. Ironside Fish & Oyster

4.6

Exceptional(4686)

$$$$Price: Moderate

• Southern american • Little Italy

Booked 108 times today

Ironside Fish & Oyster in San Diego's Little Italy is a quintessential hotspot for authentic American cuisine, seamlessly blending traditional and contemporary flavors. This gem pays homage to its roots in the fishing industry with a mouthwatering menu that features renowned dishes such as the lobster roll and clam chowder, praised for being “chock full of clams.” The vibrant atmosphere and top-notch service are frequently highlighted in reviews, with one diner noting the “excellent experience, food, and ambience.” With a stellar raw bar and an enticing happy hour, Ironside promises a “delightful experience” that diners find irresistible.

4. Brisa

new

4.2

Awesome(40)

$$$$Price: Moderate

• Southern american • Little Italy

Booked 23 times today

Brisa is a lively spot in San Diego’s Little Italy serving up bold Latin and Asian fusion flavors in a fun, laid-back setting. The menu is all about fresh ingredients and creative twists—from zesty ceviches to spicy noodles and shareable street food-inspired plates. With its vibrant, plant-filled space and upbeat vibe, Brisa is the perfect hangout for casual bites, craft cocktails, and good times with friends.

5. Craft & Commerce

4.5

Awesome(1112)

$$$$Price: Expensive

• Southern american • Little Italy

Booked 18 times today

Craft & Commerce in Little Italy, San Diego, is celebrated for its exceptional Burgers that stand out in quality and authenticity. Diners rave about the "filling and flavorful" C&C Burger, which comes perfectly paired with fries and a delectable sauce. The burger is a star on their diverse menu, often praised for its ability to satisfy even the most discerning burger enthusiasts. With an upbeat atmosphere and a team that provides top-tier service, Craft & Commerce is a must-visit for burger lovers seeking a memorable dining experience. This spot truly embodies the spirit of great Burgers cuisine, making it a local favorite.

6. Coco Maya

4.6

Exceptional(406)

$$$$Price: Expensive

• Southern american • Little Italy

Booked 13 times today

Coco Maya in Little Italy, San Diego, is a vibrant cocktail bar that elevates your dining experience with "excellent drinks and ambience." Renowned for its diverse mezcal and tequila selection, this bar seamlessly blends tropical and rum-based cocktails, a hallmark that traces back to its roots at Miss B's Coconut Club. Guests rave about the "perfectly crafted espresso martini," which stands out among their expertly curated beverages. The lively rooftop setting, often accompanied by a DJ, adds a fun and energetic vibe that enhances the entire experience. If you're seeking a memorable cocktail adventure, Coco Maya promises to deliver!

7. Petrini's

4.3

Awesome(450)

$$$$Price: Moderate

• Southern american • Little Italy

Booked 4 times today

Petrini's in San Diego's vibrant Little Italy effortlessly brings authentic American cuisine to life with their exceptional dishes. While known for its Italian roots, the restaurant's dedication to quality and authenticity shines through its American offerings. Diners rave about the "excellent food," with dishes that are "just like homemade," ensuring a genuine American experience. Patrons are drawn not only for the delightful meals but also for the "great atmosphere" and "superb service," making it a beloved neighborhood gem. Whether you’re stopping by for brunch, lunch, or dinner, Petrini's promises a memorable American dining experience that keeps guests coming back.

8. Starlite

4.7

Exceptional(184)

$$$$Price: Expensive

• Southern american • Mission Hills

Booked 101 times today

Starlite: A timeless San Diego icon with a fresh future, helmed by Chef Ted Smith.Please note: Our establishment is 21+

A photo of Rustic Root - Gaslamp restaurant

9. Rustic Root - Gaslamp

4.4

Awesome(1420)

$$$$Price: Expensive

• Southern american • Downtown

Booked 36 times today

Rustic Root showcases our take on New American Comfort food with a California twist. Classic dishes are rooted in tradition, including regional dishes from around the country. All reimagined with fresh and local ingredients and our Chef’s modern flair. Our Signature drink menus offer our take on timeless classic cocktails as well as Rustic Root originals using creative spirits and the freshest ingredients. Join us in our street-level dining room for dinner nightly or our award-winning weekend brunch. Our rooftop lounge is an excellent place to grab drinks & a bite with friends, enjoying the San Diego weather and our unique location in the heart of the Gaslamp Quarter. Close to the San Diego Convention Center, we're a favorite for locals and out of town tourists alike.

10. Books + Records

4.7

Exceptional(473)

$$$$Price: Expensive

• Southern american • Banker's Hill

Booked 8 times today

Books + Records in Banker's Hill, San Diego, is a standout Cocktail Bar, celebrated for its "inventive and creative drinks." Patrons rave about the "perfectly executed" cocktails, including unique infusions like the grey tea drink, described as "delish!" This cocktail haven consistently makes Eater's list of San Diego's Hottest Cocktail Bars, showcasing the mixology mastery of its skilled bartenders. The ambiance is lively, featuring live music that complements the vibrant atmosphere. With "attentive and friendly" service and a menu that pairs perfectly with their drinks, Books + Records offers an unmatched cocktail experience that invites you to savor every sip.

‘About the restaurant’ descriptions have been generated using an artificial intelligence model comprised of OpenTable proprietary data that has not been independently verified by OpenTable. The content is presented as-is, for informational purposes only.

Explore OpenTable

Neighborhood
Cuisine Nearby
Southern american Cuisine

Little Italy

Southern american

Pacific Beach
Menifee
San Marcos
La Jolla
Coronado
La Mesa
Poway / Rancho Bernardo
Mission Valley
Barrio Logan
Chula Vista / Bonita
Clairemont
Perris
El Cajon / Lakeside
Sorrento Valley
Temecula
Mira Mesa
Linda Vista
Grantville
Old Town
Downtown