Full list of Sal's Little Italy events can be found at www.salslittleitaly.com.
One event to definitely use your OpenTable reservation is:
The 90th Annual Feast of San Gennaro will be held in Little Italy for 11 days from Thursday, September 15, through Sunday, September 25, 2016, on the streets of historic Little Italy, the lower Manhattan neighborhood which served as the first home in America for hundreds of thousands of Italian immigrants who came here seeking to improve their lives beginning in the early part of the 20th century. quoted from www.sangennero.org
Sal's Little Italy will be posting food specials during the San Gennero festival duration.
To ensure a dining room seat during the festival, it is highly recommended to make reservations via www.opentable.com. For groups 10 or more, please use the OpenTable private dining option.