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M Brothers Restaurant - By the Medure Brothers - M Brothers at Mayo, Jacksonville, FL

M Brothers at Mayo

4.4
4.4
158 Reviews
$50 and over
Seafood
Located inside Jacksonville's Mayo Clinic, M Brothers is the newest venture by the Medure Brothers, Chef Matthew and David Medure. Our menu has a focus on fresh seafood with an Asian and Mediterranean flair. Try our signature 45-day dry aged steak. Visit our lounge for a craft cocktail or select a bottle of wine from our extensive list. Serving Lunch and Dinner Monday - Saturday.

Make a reservation

2 people

11:00 PM


Booked 5 times today

Dining areas

Additional information

  • Dining style

    Fine Dining

  • Cuisines

    Seafood, Asian, Mediterranean

  • Hours of operation

    Lunch Mon–Fri 11:00 am–2:00 pm Dinner Mon–Sat 5:00 pm–9:00 pm

  • Phone number

    (904) 953-0409

  • Dress code

    Casual Dress

Popular dishes

What 158 people are saying

Overall ratings and reviews

Reviews can only be made by diners who have eaten at this restaurant

4.4
4.4 based on recent ratings
  • 4.5Food
  • 4.4Service
  • 4.5Ambience
  • 4.1Value

NoiseModerate

Loved For

  • Jacksonville / Northeast Florida

    Fit for Foodies

  • Jacksonville / Northeast Florida

    Great for Lunch

  • Jacksonville / Northeast Florida

    Seafood

  • Jacksonville

    Fit for Foodies

  • Jacksonville

    Great for Lunch

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Filters

  1. S

    Star

    1 review

    5.0

    1 review

    Dined 3 days ago

    overall5food5service4ambience5
    I think due to our time is limited. We were hoping the service would be more timely. Other than that, everything are outstanding.
  2. p

    patti

    Minneapolis

    29 reviews

    5.0

    29 reviews

    Dined on August 12, 2022

    overall5food5service4ambience5
    Excellent food and service!
  3. 3

    3toeat

    Jacksonville

    31 reviews

    vip
    5.0

    31 reviews

    Dined on August 11, 2022

    overall5food5service5ambience5
    My friends really enjoyed their dinner! Outstanding as always!
  4. JM

    JMGator

    Jacksonville

    43 reviews

    vip
    5.0

    43 reviews

    Dined on August 11, 2022

    overall5food5service5ambience5
    You need to get over that this restaurant is at Mayo.. because the food is fantastic and different spin on the Medure restaurant. This place is great!
  5. OT

    OpenTable Diner

    Dallas

    1 review

    5.0

    1 review

    Dined on August 6, 2022

    overall5food5service4ambience5
    Food was excellent. Service was a little slow but server said it was because my medium well filet took a while to cook.
  6. J

    Jenny

    Jacksonville

    3 reviews

    5.0

    3 reviews

    Dined on August 3, 2022

    overall5food5service5ambience5
    We so enjoyed our meal and the room that allowed us the chance to talk. Thank you to all the staff for making a great lunch and get together.
  7. KK

    KevinK

    Jacksonville

    1 review

    5.0

    1 review

    Dined on August 3, 2022

    overall5food5service5ambience5
    The food was great. The service was outstanding! Jessica (Jess) was a terrific host and server! I will definitely plan to bring more clients to the restaurant. Thanks. Kevin Kinsella
  8. OT

    OpenTable Diner

    Greensboro

    1 review

    5.0

    1 review

    Dined on August 2, 2022

    overall5food5service5ambience5
    Very convenient for business meetings at Mayo. Beautiful atmosphere, food is delicious and great variety
  9. g

    ger1

    Jacksonville

    2 reviews

    5.0

    2 reviews

    Dined on August 2, 2022

    overall5food5service5ambience5
    Outstanding! Great service, excellent food and beautiful setting.
  10. OT

    OpenTable Diner

    Jacksonville

    1 review

    5.0

    1 review

    Dined on July 29, 2022

    overall5food5service5ambience5
    An excellent experience, excellent staff so helpful and knowledgeable, food was excellent.
  11. OT

    OpenTable Diner

    Jacksonville

    2 reviews

    vip
    5.0

    2 reviews

    Dined on July 27, 2022

    overall5food5service5ambience5
    Great food and service every time!
  12. S

    Sunshine

    Jacksonville

    90 reviews

    vip
    4.0

    90 reviews

    Dined on July 25, 2022

    overall4food4service5ambience5
    What a great addition to have a Medure Birthers restaurant at Mayo- Florida. Only negative comment was the roasted vegetable salad. Not a great variety of vegetable and little taste. Sent it back an replaced it with a great Beet Salad. We'll done by the staff to change out our selection
  13. T

    Taipan

    Jacksonville

    22 reviews

    vip
    3.0

    22 reviews

    Dined on July 22, 2022

    overall3food4service3ambience4
    Were told they needed us to hurry to make our food selections as they only had ten menus Our waitress was professional but hurried as her stations were spread over the width of the restaurant due to staff shortages
  14. JK

    JohnK

    1 review

    5.0

    1 review

    Dined on July 22, 2022

    overall5food5service5ambience5
    Wonderful new restaurant. Needs better signage on how to get to it and where to park.
  15. AO

    AleathaO

    Jacksonville

    8 reviews

    vip
    5.0

    8 reviews

    Dined on July 21, 2022

    overall5food5service5ambience5
    Elevated dining experience, beautiful design & fantastic service.
  16. ME

    MaryE

    Jacksonville

    10 reviews

    vip
    4.0

    10 reviews

    Dined on July 19, 2022

    overall4food4service5ambience4
    We enjoyed our dinner and evening at M Brothers last night. Our waiter, Dillon, did a terrific job helping me avoid salt and other health-based dietary restrictions by modifying an entree for me. My husband, however, was a bit disappointed in his short rib entree. It was good, but the meat wasn't as tender as he had hoped. We wish the restaurant continued success and will return.
  17. j

    jburthunt

    Jacksonville

    20 reviews

    vip
    5.0

    20 reviews

    Dined on July 16, 2022

    overall5food5service5ambience5
    Excellent service and great selections for cocktails and the specials are always wonderfully prepared. Love this new Medure restaurant!!
  18. OT

    OpenTable Diner

    Jacksonville

    2 reviews

    vip
    5.0

    2 reviews

    Dined on July 15, 2022

    overall5food5service5ambience5
    Outstanding food. Excellent service.
  19. JT

    JanT

    Jacksonville

    3 reviews

    5.0

    3 reviews

    Dined on July 14, 2022

    overall5food5service5ambience5
    Great for lunch, have not been to use supper menu yet.
  20. OT

    OpenTable Diner

    Orlando

    1 review

    5.0

    1 review

    Dined on July 14, 2022

    overall5food5service3ambience5
    Absolutely beautiful venue. Fantastic chef. The service was a little slow but our server was fantastic!
  21. OT

    OpenTable Diner

    Jacksonville

    11 reviews

    3.0

    11 reviews

    Dined on July 8, 2022

    overall3food3service5ambience5
    This dinner was for our 1st wedding anniversary so we wanted to pick a place we don’t usually go to. I was so disappointed in the quality of the food. We ordered 1/2 dozen oysters to start and they were tiny about the size of a nickel. I then ordered the beet salad which was fabulous. Delicious and tasty with just the right amount of dressing. I ordered the seafood pappardelle which was so good with a not too heavy Parmesan cream sauce and my husband ordered the 28 day ribeye. He asked the waiter if the chef would cook above or below the desired temperature and was assured he would be spot on. My husband ordered it medium rare and the steak was so over cooked. They did offer to remake it but at that time my food was at the table and I had begun eating it. The waiter offered to comp dessert. That was nice but the ribeye was $85. I didn’t realize that my husband went to talk to the manager and she did comp the steak. Overall, I’m not sure I would return which is such a letdown because I love so many of the Medure Brothers restaurants
  22. KV

    KaajandVik

    Jacksonville

    34 reviews

    vip
    5.0

    34 reviews

    Dined on July 5, 2022

    overall5food4service5ambience5
    Great decor and ambience. Service was very good and food was delicious. Definitely a little on the pricey side so nice for a special occasion. Location was a little confusing as inside the Mayo hospital and no signs on the Main Street so took us awhile to find. Free parking and valet. Love the concept of having a nice restaurant inside the hospital. Definitely be back.
  23. RC

    RCRC

    Washington DC

    18 reviews

    vip
    4.0

    18 reviews

    Dined on June 29, 2022

    overall4food4service4ambience4
    There is an air freshener that is very strong in the larger dining room. Totally unnecessary and ruined the experience until we had to be moved. Please address this. I am staff at Mayo and will be bringing several colleagues for dining in the future. Thanks!
  24. a

    atlanticbeachdiner

    Jacksonville

    5 reviews

    vip
    5.0

    5 reviews

    Dined on June 29, 2022

    overall5food5service5ambience5
    Everything the Medure brothers do is excellent and this is no exception. The service and all of the food were outstanding!
  25. GS

    GeorgeS

    Jacksonville

    4 reviews

    5.0

    4 reviews

    Dined on June 20, 2022

    overall5food5service5ambience5
    This is a fabulous addition to Mayo Clinic. A quiet, elegant full service restaurant with an imaginative menu, flawlessly prepared food and excellent unhurried service.
  26. H

    Hearttoeat

    New Orleans

    5 reviews

    vip
    4.0

    5 reviews

    Dined on June 17, 2022

    overall4food5service5ambience5
    The prices were very high. Would have liked to have seen some of the more wallet friendly items from the lunch menu on the dinner menu.
  27. D

    Diner3

    Jacksonville

    5 reviews

    2.0

    5 reviews

    Dined on June 17, 2022

    overall2food2service2ambience3
    Difficult to locate - no signage. Staff rushed us. Presentation was lacking. Shrimp overcooked. Expectations were sky high - as we are regulars at other M Brothers establishments - Needless to say were were SEVERELY DISAPPOINTED.
  28. c

    charlesf

    Washington DC

    6 reviews

    vip
    5.0

    6 reviews

    Dined on June 15, 2022

    overall5food5service5ambience5
    Incredible service world-class cuisine absolutely enjoy the crispy red snapper. The appetizers were absolutely incredible and the service was i phenomenal. I will give my highest recommendation for a restaurant
  29. G

    Goldi

    Jacksonville

    56 reviews

    vip
    4.0

    56 reviews

    Dined on June 14, 2022

    overall4food5service3ambience4
    The food is excellent. Our group of 4 had oysters and the scallop special for appetizers. All very good. For entrees we had the fish of the night (snapper) meuniere served with mashed potatoes, sautéed spinach, and artichoke hearts. The fish was a tad dry but overall everything was good. Crème brulée, chocolate bread pudding, and ice cream finished off the meal. The service seemed to be slow even though there were not many diners. You will not be disappointed.
  30. OT

    OpenTable Diner

    Jacksonville

    3 reviews

    5.0

    3 reviews

    Dined on June 9, 2022

    overall5food4service5ambience5
    Staff was wonderful. Food was very good.
  31. GS

    GeneS

    1 review

    2.0

    1 review

    Dined on June 7, 2022

    overall2food1service1ambience2
    Scallops badly cooked, sauce broken on plate. Obsequious but somehow also inefficient wait staff. Ambiance not great. In short, not worth the price
  32. TT

    TerryT

    Jacksonville

    1 review

    vip
    5.0

    1 review

    Dined on June 4, 2022

    overall5food5service5ambience5
    Awesome good job!
  33. F

    Foodie79

    1 review

    2.0

    1 review

    Dined on June 1, 2022

    overall2food1service1ambience3
    With fine dinning you expect the food and service to be at a certain level. The food was bland and our server disappeared before taking our orders for 20 min. They are very short staffed and we felt others were catered to on a different level. Will never return.
  34. t

    theplanner

    Jacksonville

    36 reviews

    vip
    3.0

    36 reviews

    Dined on May 28, 2022

    overall3food3service2ambience4
    this was our biggest disappointment from any Medure restaurant we have visited--the service was horrible, had to ask for salt and pepper 3 times, ordered bread service to enjoy with lobster bisque and it did not arrive on the table until we had already finished our bisque--ridiculous!!!!! My out of town guest's steak was barely warm, my wife hated her salad, and her chicken with vegetables were barely visible==took forever to get butter, ordered a soft drink with limes, and got a soft drink with no limes so had to order again---M brothers at Mayo will not be seeing us again for a long long long time.....horrible experience..........
  35. EN

    ErikN

    San Francisco

    27 reviews

    3.0

    27 reviews

    Dined on May 28, 2022

    overall3food3service3ambience3
    Very quite night. I understand that starting a restaurant inside a major hospital is quite a venture and struggle. Signage is poor. You must essentially call to find out how to get there. Almost impossible otherwise. Limited supplies, perhaps due to limited volume of customers. Did not have the first thing on the menu I ordered. Rib eye was replaced with a non-dry aged version. The pepperadelle was great. The bread pudding was great. Popcorn shrimp was interesting indeed and worthy of trying. Nothing spectacular. Quiet location, total of 8 tables occupied during our 90 minute stay. Good food. Nothing unique or precedent setting.
  36. C

    Cher0317

    1 review

    3.0

    1 review

    Dined on May 27, 2022

    overall3food2service4ambience3
    Lobster rolls were inedible. Meat was chewy and slaw over powered the lobster. Hamburger was good, cooked just tight.
  37. KL

    KathleenL

    New York Area

    3 reviews

    5.0

    3 reviews

    Dined on May 23, 2022

    overall5food5service5ambience5
    Great bartender. Makes his own concoctions and they are yummy. Food and service was great! Very nice to have such a great restaurant so convenient for those at the Mayo Clinic.
  38. OT

    OpenTable Diner

    Las Vegas

    1 review

    2.0

    1 review

    Dined on May 21, 2022

    overall2food4service3ambience1
    Totally overpriced as compared to all other fine dining in Jax
  39. DK

    DKFL

    Jacksonville

    52 reviews

    3.0

    52 reviews

    Dined on May 21, 2022

    overall3food3service4ambience3
    The food was merely average in preparation. Definitely did not meet our expectations. Glad we had the experience; will go someplace else with more upscale preparation for a special night out. A pricey tab for a ho-hum meal.
  40. OT

    OpenTable Diner

    Denver

    2 reviews

    vip
    5.0

    2 reviews

    Dined on May 17, 2022

    overall5food5service5ambience5
    Eight of us had a wonderful dinner in the round wine room. Everything was terrific…from good drinks to start to final birthday cake serving. Jessica, our server, took exceptional care of us. We really appreciated the manager inviting us to order our dinners before a party of 30 did…made all the difference in our dinners arriving at pace and being perfectly prepared. At least six times a year we celebrate one or more members’ birthdays. M Brothers at Mayo is our favorite celebration place for the special event. Thanks.

FAQs

M Brothers at Mayo is rated 4.4 stars by 158 OpenTable diners.

Yes, you can generally book this restaurant by choosing the date, time and party size on OpenTable.

Make a reservation

2 people

11:00 PM


Booked 5 times today
Google Map for M Brothers at Mayo

14335 Hospital Drive Suite 100, Jacksonville, FL 32224

Dining areas

Additional information

  • Cross street

    San Pablo to W. Davis. Turn into Garage and look for complimentary VALET.

  • Neighborhood

    Jacksonville

  • Hours of operation

    Lunch Mon–Fri 11:00 am–2:00 pm Dinner Mon–Sat 5:00 pm–9:00 pm

  • Cuisines

    Seafood, Asian, Mediterranean

  • Dining style

    Fine Dining

  • Dress code

    Casual Dress

  • Parking details

    Valet

  • Additional

    Bar/Lounge, Chef's Table, Non-Smoking, Private Room

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