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M Brothers Restaurant - By the Medure Brothers - M Brothers at Mayo, Jacksonville, FL

M Brothers at Mayo

4.7
4.7
523 Reviews
$50 and over
Seafood
14335 Hospital Drive Suite 100, Jacksonville, FL 32224

Make a reservation

2 people
7:00 PM
Booked 18 times today
Experiences are available.

About this restaurant

  • Good for business meals
  • Good for special occasions
  • Innovative
M Brothers at Mayo is a hidden gem tucked inside Jacksonville’s Mayo Clinic—a delightful reprieve where culinary excellence meets refined hospitality. A Medure Brothers Culinary Concept by acclaimed chefs Matthew and David Medure, M Brothers is led by Executive Chef Thomas Rivers and offers a sophisticated dining experience on Mayo Clinic's campus.

Enjoy globally inspired cuisine crafted with seasonal ingredients, and don’t miss our monthly Culinary Passport tasting menus, where we explore flavors from a different region of the world each month.

Visit our lounge for a handcrafted cocktail or select a bottle from our extensive wine list. Join us for Lunch Monday–Friday and Dinner Monday–Saturday. Unwind during Happy Hour in the lounge, Monday–Friday from 4–6 PM.

Whether you're sampling guest favorites like our burrata appetizer, savory shrimp étouffée, or a seasonal chef-driven entrée, M Brothers is a destination worth discovering.

Dining areas

Additional information

  • Dining style
    Fine Dining
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Hours of operation
    Lunch Mon–Fri 11:00 am–2:00 pm Dinner Mon–Sat 5:00 pm–9:00 pm
  • Phone number
  • Dress code
    Casual Dress

Experiences

  • Culinary Passport: Korea

    $90.00 - $135.00 per person

    May 24, 2025 only
    Culinary Passport: Korea Join us at M Brothers on Saturday, May 24, 2025, for the next stop on our Culinary Passport Dinners series! Indulge in a 4-course tasting menu celebrating the bold and diverse flavors of Korea. Experience a thoughtfully crafted selection of dishes that highlight the essence of this vibrant cuisine. This experience is priced at $90 per person, or elevate your meal with curated wine or alcohol pairings for each course for $135. This exclusive menu will ONLY be available on May 24th—don’t miss this unforgettable taste of Korea! 🇰🇷✨
  • Culinary Passport: French Riviera

    $90.00 - $135.00 per person

    Jun 21, 2025 only
    Join us at M Brothers on Saturday, June 21, 2025, for the next stop on our Culinary Passport Dinners series! Indulge in a 4-course tasting menu inspired by the fresh, vibrant flavors of the French Riviera. Enjoy a thoughtfully crafted selection of dishes that capture the essence of this sun-drenched coastal region. This experience is priced at $90 per person, or elevate your meal with curated wine or alcohol pairings for each course for $135. This exclusive menu will ONLY be available on June 21st—don’t miss this unforgettable taste of the French Riviera! 🇫🇷✨

What 523 people are saying

M Brothers at Mayo reviews from people who’ve dined at this restaurant. Based on recent rating.

Overall ratings and reviews

Reviews can only be made by diners who have eaten at this restaurant

4.7
4.7 based on recent ratings
  • 4.7Food
  • 4.7Service
  • 4.6Ambience
  • 4.4Value

NoiseModerate

Loved For

  • Jacksonville / Northeast Florida

    Healthy

  • Jacksonville / Northeast Florida

    Seafood

  • Jacksonville

    Best Overall

  • Jacksonville

    Best Value

  • Jacksonville

    Innovative

  • Jacksonville

    Healthy

Review summary

AI-generated from verified diner reviews
M Brothers at Mayo offers a "wonderful experience" with "excellent food, service, and ambience." Located conveniently at the Mayo Clinic, it features a "beautifully designed" setting with live music and a welcoming atmosphere. The menu is "innovative and delicious," and the staff, including standout servers like Destiny and Kaely, provide attentive service. Highly recommended for a relaxing dining experience.

523 Reviews
  1. Gail

    Jacksonville3 reviews

    5.0

    Dined 1 day ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Always a pleasure to visit M Brothers when at Mayo. We sit in the bar area because it is relaxed and the service team there is fantastic. Makes a visit to Mayo not so hard too. Food is always top shelf.

    Is this helpful?

  2. Carol VIP

    Jacksonville12 reviews

    5.0

    Dined on April 19, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 4
    We always have a great meal and great time at the M Brothers Tasting meals. This one was by far the best one yet. As always all of the staff are great but Kaely is the best! :)
    M Brothers at MayoResponded 6 days ago
    Thank you so much! We're thrilled to hear the Florence Culinary Passport dinner was your favorite tasting yet. We'll be sure to pass the love along to Kaely—she'll be so happy to hear it!

    Is this helpful?

  3. Debra

    Jacksonville15 reviews

    5.0

    Dined on April 19, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    The Florence, Italy tour food was amazing. Destiny, our waitress, was outstanding. She made it a more enjoyable meal.
    M Brothers at MayoResponded 6 days ago
    Thank you, Debbie and John! We’re so glad you enjoyed the Florence, Italy Culinary Passport Dinner—and we couldn’t agree more, Destiny is fantastic! We’ll be sure she sees your kind words. Can’t wait to have you back soon!

    Is this helpful?

  4. jose VIP

    Orlando2 reviews

    1.0

    Dined on April 19, 2025

    1. Overall 1
    2. Food 1
    3. Service 1
    4. Ambience 1
    I love their restaurants, but this one was way below their standards of food quality and service. Mathew’s Medure and midtown table and M shack are great places not sure what happened here.
    M Brothers at MayoResponded on April 22, 2025
    Thank you for your feedback. We're truly sorry to hear that your experience at M Brothers didn’t meet expectations. Our general manager, Dalvin, appreciated the opportunity to speak with you directly. We’re grateful for your support of our other concepts and would love the opportunity to welcome you back and provide the level of food and service you’ve come to expect from us.

    Is this helpful?

  5. Jerry

    Tallahassee14 reviews

    5.0

    Dined on April 15, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    As has always been our experience, dinner at M Brothers at Mayo was a delightful experience. The cuisine, staff and ambience were excellent. Convenience of location at Mayo is perfect. Highly recommended.
    M Brothers at MayoResponded on April 18, 2025
    Thank you for your continued support and thoughtful review! We're so glad to hear each visit has been a delightful experience. We truly appreciate the recommendation and look forward to welcoming you back soon!

    Is this helpful?

  6. Larry VIP

    Jacksonville19 reviews

    4.0

    Dined on April 11, 2025

    1. Overall 4
    2. Food 5
    3. Service 4
    4. Ambience 4
    Kayle and chief executive produced a delightful evening of good food and wine service. Our friends enjoyed it as well. Larry
    M Brothers at MayoResponded on April 18, 2025
    Thank you, Larry! We’re so glad you and your friends had a great evening. We appreciate your kind words and look forward to welcoming you back!

    Is this helpful?

  7. maryori VIP

    Charlotte4 reviews

    5.0

    Dined on April 11, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Wonderful experience. Food and service was excellent

    Is this helpful?

  8. George VIP

    New York City31 reviews

    4.0

    Dined on April 7, 2025

    1. Overall 4
    2. Food 3
    3. Service 3
    4. Ambience 4
    The poke bowl should have been made with sushi rice - not regular white rice. It was not possible to eat with chopsticks. Also, I asked for some soy sauce and was not served it.

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  9. Alan VIP

    Jacksonville79 reviews

    3.0

    Dined on April 4, 2025

    1. Overall 3
    2. Food 3
    3. Service 4
    4. Ambience 4
    The wine room was perfect, intimate and quiet. The service was very good, but the restaurant was almost empty on Friday night. The food was excellent until the dessert. The ribeye, the tenderloin and salmon salad were delicious. The bread plate app was really good. However, the whole experience ended badly with carrot cake that was barely edible and bread pudding served cold. Unacceptable.
    M Brothers at MayoResponded on April 7, 2025
    Thank you for sharing your feedback. We’re happy to hear you enjoyed the wine room, service, and your main courses. However, we’re sorry the dessert didn’t meet your expectations and this is not the standard we strive for. Our General Manager, Dalvin, would love to connect with you to make things right. We look forward to the opportunity to welcome you back.

    Is this helpful?

  10. Thomas

    Orlando8 reviews

    5.0

    Dined on April 3, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 4
    This is an excellent restaurant. Our 2nd visit (party of 2) to this location inside the Mayo Clinic in Jacksonville, FL. Service has been great with courses spaced nicely apart. We had made reservations and were promptly seated.
    M Brothers at MayoResponded on April 11, 2025
    Thank you for your continued support! We're glad to hear your second visit was just as enjoyable, with great service and pacing. We look forward to welcoming you back again soon!

    Is this helpful?

FAQs

M Brothers at Mayo is rated 4.7 stars by 523 OpenTable diners.

Yes, you can generally book this restaurant by choosing the date, time and party size on OpenTable.

  1. Home
  2. United States
  3. Jacksonville / Northeast Florida
  4. Jacksonville
  5. Jacksonville

Make a reservation

2 people
7:00 PM
Booked 18 times today
Experiences are available.
Google Map for M Brothers at Mayo

14335 Hospital Drive Suite 100, Jacksonville, FL 32224

Dining areas

Additional information

  • Cross street
    San Pablo to W. Davis. Turn into Garage and look for complimentary VALET.
  • Neighborhood
    Jacksonville
  • Hours of operation
    Lunch Mon–Fri 11:00 am–2:00 pm Dinner Mon–Sat 5:00 pm–9:00 pm
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Dining style
    Fine Dining
  • Dress code
    Casual Dress
  • Parking details
    Valet
  • Additional
    Bar/Lounge, Chef's Table, Non-Smoking, Private Room
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