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M Brothers Restaurant - By the Medure Brothers - M Brothers at Mayo, Jacksonville, FL

M Brothers at Mayo

4.7 (531)
$50 and over
Seafood
14335 Hospital Drive Suite 100, Jacksonville, FL 32224

Make a reservation

2 people
7:00 PM
Booked 11 times today
Experiences are available.

About this restaurant

  • Good for special occasions
  • Good for business meals
  • Innovative
M Brothers at Mayo is a hidden gem tucked inside Jacksonville’s Mayo Clinic—a delightful reprieve where culinary excellence meets refined hospitality. A Medure Brothers Culinary Concept by acclaimed chefs Matthew and David Medure, M Brothers is led by Executive Chef Thomas Rivers and offers a sophisticated dining experience on Mayo Clinic's campus.

Enjoy globally inspired cuisine crafted with seasonal ingredients, and don’t miss our monthly Culinary Passport tasting menus, where we explore flavors from a different region of the world each month.

Visit our lounge for a handcrafted cocktail or select a bottle from our extensive wine list. Join us for Lunch Monday–Friday and Dinner Monday–Saturday. Unwind during Happy Hour in the lounge, Monday–Friday from 4–6 PM.

Whether you're sampling guest favorites like our burrata appetizer, savory shrimp étouffée, or a seasonal chef-driven entrée, M Brothers is a destination worth discovering.

Dining areas

Additional information

  • Dining style
    Fine Dining
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Hours of operation
    Lunch Mon–Fri 11:00 am–2:00 pm Dinner Mon–Sat 5:00 pm–9:00 pm
  • Phone number
  • Dress code
    Casual Dress

Experiences

  • Culinary Passport: French Riviera

    $90.00 - $135.00 per person

    Jun 21, 2025 only
    Join us at M Brothers on Saturday, June 21, 2025, for the next stop on our Culinary Passport Dinners series! Indulge in a 4-course tasting menu inspired by the fresh, vibrant flavors of the French Riviera. Enjoy a thoughtfully crafted selection of dishes that capture the essence of this sun-drenched coastal region. This experience is priced at $90 per person, or elevate your meal with curated wine or alcohol pairings for each course for $135. This exclusive menu will ONLY be available on June 21st—don’t miss this unforgettable taste of the French Riviera! 🇫🇷✨

What 531 people are saying

M Brothers at Mayo reviews from people who’ve dined at this restaurant. Based on recent rating.

Overall ratings and reviews

Reviews can only be made by diners who have eaten at this restaurant

4.7
4.7 based on recent ratings
  • 4.7Food
  • 4.7Service
  • 4.6Ambience
  • 4.4Value

NoiseModerate

Loved For

  • Jacksonville / Northeast Florida

    Innovative

  • Jacksonville / Northeast Florida

    Seafood

  • Jacksonville

    Innovative

  • Jacksonville

    Healthy

Review summary

AI-generated from verified diner reviews
M Brothers at Mayo offers an "excellent quality" dining experience with "beautifully prepared and presented" dishes. Located within the Mayo Clinic, it surprises with "outstanding" service and cuisine. Known for its "fantastic" monthly passport tasting menu and "great" wine pairings, the restaurant is a "hidden gem" offering both elegance and convenience.
531 Reviews
  1. Alisa

    Jacksonville / Northeast Florida2 reviews

    5.0

    Dined on May 31, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    M Brothers is Jacksonville's best kept secret. One would not expect such a high level of dining from a restaurant located inside of a clinic, but it is outstanding. Dalvin over see all details to make everyone's dining experience one to remember.
    M Brothers at MayoResponded on June 6, 2025
    Alisa, thank you for the wonderful compliment! We're proud to offer exceptional dining at M Brothers, and Dalvin will be thrilled to hear your kind words!

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  2. Jim VIP

    Jacksonville / Northeast Florida21 reviews

    5.0

    Dined on May 24, 2025

    1. Overall 5
    2. Food 4
    3. Service 5
    4. Ambience 4
    Dalvin and his team always provide excellence service and dining experience. Jessica and Chauntelle helped make the evening special.
    M Brothers at MayoResponded on May 30, 2025
    Thank you for the kind words and continued support! We're so glad Dalvin, Jessica, and Chauntelle helped make your evening special. We look forward to welcoming you back soon!

    Is this helpful?

  3. Ellwood VIP

    New York City16 reviews

    5.0

    Dined on May 24, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    The Korea experience was fantastic. We would not miss the monthly passport tasting menu.
    M Brothers at MayoResponded on May 30, 2025
    Thank you! We're thrilled you enjoyed the Korea experience and appreciate your enthusiasm for the Passport series. We can’t wait to share the next destination with you!

    Is this helpful?

  4. Caroline

    London3 reviews

    5.0

    Dined on May 19, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Excellent quality, beautifully prepared and presented. Really enjoyed ourselves and will certainly come back.
    M Brothers at MayoResponded on May 23, 2025
    Thank you! We’re glad you enjoyed the quality and presentation. Looking forward to welcoming you back!

    Is this helpful?

  5. H VIP

    Jacksonville / Northeast Florida15 reviews

    5.0

    Dined on May 16, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Our first visit and we were very pleased with our experience.
    M Brothers at MayoResponded on May 23, 2025
    Thank you for choosing to visit us! We’re glad you had a great experience and hope to see you again soon.

    Is this helpful?

  6. Gordon VIP

    Jacksonville / Northeast Florida73 reviews

    5.0

    Dined on May 14, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Everything was excellent, which is what we've come to expect from any Medure brother's restaurant. I think that we've now visited all of them and M Brothers lives up to the rep of the other restaurants. We will definitely be back.
    M Brothers at MayoResponded on May 16, 2025
    Thank you so much for your continued support and for visiting all of our restaurants! We’re thrilled to hear M Brothers lived up to your expectations, and we can’t wait to welcome you back soon.

    Is this helpful?

  7. Bernard VIP

    Jacksonville / Northeast Florida81 reviews

    5.0

    Dined on May 10, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    We had a wonderful dinner at M Brothers at Mayo. The flounder stuffed with crab was perfectly prepared. In all this is a great restaurant with excellent people.
    M Brothers at MayoResponded on May 16, 2025
    Thank you for the lovely review! We’re so happy you enjoyed your dinner and that the flounder stood out. It means a lot to hear such kind words about our team—we look forward to welcoming you back!

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  8. Frank

    Jacksonville / Northeast Florida18 reviews

    5.0

    Dined on May 5, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Great food and service. The location in a hospital may give you pause but the ambience once inside the restaurant is incredible and you will not find better service.
    M Brothers at MayoResponded on May 9, 2025
    Thanks so much! We love being a hidden gem—can’t wait to welcome you back!

    Is this helpful?

  9. Gail

    Jacksonville / Northeast Florida3 reviews

    5.0

    Dined on April 30, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Always a pleasure to visit M Brothers when at Mayo. We sit in the bar area because it is relaxed and the service team there is fantastic. Makes a visit to Mayo not so hard too. Food is always top shelf.
    M Brothers at MayoResponded on May 2, 2025
    Thank you for the kind words and continued support! We're so glad the bar area provides a comfortable and welcoming spot during your visits to Mayo. It means a lot to hear our team and food help make your time here a little easier. We look forward to seeing you again soon!

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  10. Carol VIP

    Jacksonville / Northeast Florida12 reviews

    5.0

    Dined on April 19, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 4
    We always have a great meal and great time at the M Brothers Tasting meals. This one was by far the best one yet. As always all of the staff are great but Kaely is the best! :)
    M Brothers at MayoResponded on April 25, 2025
    Thank you so much! We're thrilled to hear the Florence Culinary Passport dinner was your favorite tasting yet. We'll be sure to pass the love along to Kaely—she'll be so happy to hear it!

    Is this helpful?

FAQs

M Brothers at Mayo is rated 4.7 stars by 531 OpenTable diners.

Yes, you can generally book this restaurant by choosing the date, time and party size on OpenTable.

  1. Home
  2. United States
  3. Jacksonville / Northeast Florida
  4. Jacksonville
  5. Jacksonville

Make a reservation

2 people
7:00 PM
Booked 11 times today
Experiences are available.
Google Map for M Brothers at Mayo

14335 Hospital Drive Suite 100, Jacksonville, FL 32224

Dining areas

Additional information

  • Cross street
    San Pablo to W. Davis. Turn into Garage and look for complimentary VALET.
  • Neighborhood
    Jacksonville
  • Hours of operation
    Lunch Mon–Fri 11:00 am–2:00 pm Dinner Mon–Sat 5:00 pm–9:00 pm
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Dining style
    Fine Dining
  • Dress code
    Casual Dress
  • Parking details
    Valet
  • Additional
    Bar/Lounge, Chef's Table, Non-Smoking, Private Room
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