Midtown Restaurants

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Best American Restaurants in Midtown

Three Kings Public House - The LoopThree Kings Public House - The Loop
(252)
$$$$
American | The Loop, Midtown
Edibles & EssentialsEdibles & Essentials
(10)
$$$$
American | St. Louis Hills, Midtown
The Ritz-Carlton RestaurantThe Ritz-Carlton Restaurant
(123)
$$$$
American | Clayton, Midtown
Booked 2 times today
AvenueAvenue
(338)
$$$$
American | Clayton, Midtown
Booked 9 times today
Herbie'sHerbie's
(1195)
$$$$
American | Clayton, Midtown
Booked 21 times today
BoundaryBoundary
(380)
$$$$
American | Clayton, Midtown
Booked 34 times today
TGI FRIDAYS - Creve CoeurTGI FRIDAYS - Creve Coeur
(11)
$$$$
American | Creve Coeur, Midtown
Booked 4 times today
TGI FRIDAYS - Fairview HeightsTGI FRIDAYS - Fairview Heights
(16)
$$$$
American | Fairview Heights, Midtown
Booked 2 times today
Annie Gunn'sAnnie Gunn's
(2331)
$$$$
American | Chesterfield, West County
Booked 30 times today
Spiro's - St. CharlesSpiro's - St. Charles
(14)
$$$$
American | Maryland Heights, West County
Booked 5 times today
Anthony's BarAnthony's Bar
(128)
$$$$
American | Downtown St. Louis, Downtown
Booked 4 times today
Billy G'sBilly G's
(69)
$$$$
American | Kirkwood, West County
Booked 4 times today
Prasino - St. Charles, MOPrasino - St. Charles, MO
(1476)
$$$$
American | St. Charles, West County
Booked 36 times today
Frazer's Restaurant & LoungeFrazer's Restaurant & Lounge
(232)
$$$$
American | Soulard / Benton Park, Downtown
Booked 11 times today
Bishop's PostBishop's Post
(478)
$$$$
American | Chesterfield, West County
Booked 25 times today
Scape American BistroScape American Bistro
(1365)
$$$$
American | Central West End, Downtown
Booked 30 times today
Balaban's - ChesterfieldBalaban's - Chesterfield
(280)
$$$$
American | Chesterfield, West County
Booked 3 times today
Cardinals NationCardinals Nation
(356)
$$$$
American | Downtown St. Louis, Downtown
Booked 4 times today
Cedar Lake CellarsCedar Lake Cellars
(52)
$$$$
American | O'Fallon, West County
Booked 7 times today

Best Italian Restaurants in Midtown

AceroAcero
(930)
$$$$
Italian | Maplewood, Midtown
Booked 9 times today
Café NapoliCafé Napoli
(1146)
$$$$
Italian | Clayton, Midtown
Booked 23 times today
Katie's Pizza & Pasta Osteria - Rock HillKatie's Pizza & Pasta Osteria - Rock Hill
(570)
$$$$
Italian | Rock Hill, Midtown
Booked 24 times today
IL Bel Lago - From the HillIL Bel Lago - From the Hill
(376)
$$$$
Italian | Creve Coeur, Midtown
Booked 9 times today
SardellaSardella
(289)
$$$$
Italian | Clayton, Midtown
Booked 49 times today
Giovanni's KitchenGiovanni's Kitchen
(450)
$$$$
Italian | Clayton, Midtown
Booked 15 times today
Tavolo VTavolo V
(242)
$$$$
Italian | The Loop, Midtown
Booked 15 times today
Maggiano's - St. LouisMaggiano's - St. Louis
(5108)
$$$$
Italian | Richmond Heights, Midtown
Booked 97 times today
BassoBasso
(593)
$$$$
Italian | Clayton, Midtown
Booked 10 times today
Napoli 2Napoli 2
(1166)
$$$$
Italian | Chesterfield, West County
Booked 20 times today
Tony's - St. LouisTony's - St. Louis
(1136)
$$$$
Italian | St. Louis, Downtown
Booked 7 times today
Charlie Gitto's 'On the Hill'Charlie Gitto's 'On the Hill'
(3138)
$$$$
Italian | The Hill, Downtown
Booked 45 times today
Sapore Italian CafeSapore Italian Cafe
(93)
$$$$
Italian | Kirkwood, West County
Booked 5 times today
Eleven Eleven MississippiEleven Eleven Mississippi
(2850)
$$$$
Italian | Soulard / Benton Park, Downtown
Booked 43 times today
Charlie Gitto's at Hollywood CasinoCharlie Gitto's at Hollywood Casino
(1050)
$$$$
Italian | Maryland Heights, West County
Booked 13 times today
Charlie Gitto's from the Hill - ChesterfieldCharlie Gitto's from the Hill - Chesterfield
(1275)
$$$$
Italian | Chesterfield, West County
Booked 24 times today

Popular restaurants in St. Louis

Browse some of the most booked restaurants in St. Louis

BRIO Tuscan Grille - St. Louis - Frontenac
(171)
$$$$
Italian | Frontenac
Sardella
(108)
$$$$
Italian | Clayton
The Capital Grille - St. Louis - Clayton
(282)
$$$$
Steakhouse | Clayton
View all St. Louis restaurants

Treat your taste buds: Explore Midtown restaurants.

Diners' Choice Winners: Best Overall

Midtown's best restaurants based upon thousands of OpenTable diner reviews
Acero1. Acero
930 reviews
$$$$
Italian | Maplewood, Midtown
Booked 9 times today

Great food and service. This place stands up to the rest of time. Egg yolk raviolo as excellent as I️ remember it More

OpenTable Diner -
The Crossing2. The Crossing
877 reviews
$$$$
French | Clayton, Midtown
Booked 18 times today

Lucky enough to get the table for 2 tucked in the corner of the upper level. Once a table of 4 ladies cleared out, it was nice and peaceful. My wife had the premium tasting menu and I the tile fish special. The tasting menu was a good deal at $50 (I ate probably 1/3 of my wife’s), but the tile fish (although perfectly prepared and tasty) was maybe overpriced by $3-4. Anyway, the service was excellent and by and large, the overall experience was top notch. More

OpenTable Diner -
Truffles - St. Louis3. Truffles - St. Louis
720 reviews
$$$$
Contemporary American | Clayton, Midtown
Booked 17 times today

The salads were small for side salad let alone a main. At $14 expected a larger one. The food was excellent. More

OpenTable Diner -
The Capital Grille - St. Louis - Clayton4. The Capital Grille - St. Louis - Clayton
44 reviews
$$$$
Steakhouse | Clayton, Midtown
Booked 31 times today

Great food and service. Went for my Dad’s birthday and the entire staff made sure it was special. More

OpenTable Diner -
IL Bel Lago - From the Hill5. IL Bel Lago - From the Hill
376 reviews
$$$$
Italian | Creve Coeur, Midtown
Booked 9 times today

Always a great dinner! We enjoy Steve as our waiter, every visit! But we do miss the music in the bar! More

OpenTable Diner -

New to OpenTable

Midtown restaurants that recently joined the OpenTable network
Granite City Food & Brewery - Creve CoeurGranite City Food & Brewery - Creve Coeur
$$$$
American | Creve Coeur, Midtown
Booked 9 times today

Granite City Food & Brewery features signature menu items and proprietary beers in a polished casual setting. Menu items include Broad Axe stout beer short ribs, ponzu glazed salmon, and maple pepper bacon flatbreads.


Signature GCFB beers are brewed onsite, including: the Batch 1000 Double IPA, the Bennie German Bock, the Broad Axe Oatmeal Stout, Duke Pale Ale, and the Prairie Vixen Hefeweizen, are complemented by a rotating selection of seasonal and specialty brews.More

Discover Clayton

St. Louis, Missouri's inner-ring suburb of Clayton is known as not only the seat of St. Louis’s city government but also the spot for shopping, dining, and upscale hotels. A Taste of Clayton food festival is held here annually. Because “St. Louis’s second downtown” is a business hub, the dining atmosphere tends to be a hybrid of upscale and casual, with many restaurants that attract a business crowd. St. Louis barbecue is represented, along with burgers and Black Angus steaks. Visitors may be surprised to find many Italian influences along with a few bistros serving French-style food and more traditionally American pub food choices. The pedestrian-friendly neighborhood also offers sushi, vegetarian fare, and an espresso bar.