Best Southern American Restaurants in Mission District

Price

$$
$$$
$$$$

Regions

East BayMarinPeninsulaSan Francisco

Neighborhoods

AlamedaBerkeleyBernal HeightsCivic Center / Hayes Valley / Van NessCole ValleyCow Hollow

Top Rated

CharmingFancyGood for business mealsGood for groupsGood for special occasionsGreat for brunch

Dining Options

All dining options

Delivery only

Takeout only

Seating Options

BarCounterStandardHigh TopOutdoor

Award-winning

MICHELINWorld's 50 Best

Accessibility

Wheelchair access

148 restaurants available nearby

How are Featured results ranked

1. Curio

4.4

Awesome(325)

$$$$Price: Moderate

• Southern american • Mission District

Booked 3 times today

Curio, located in the vibrant Mission District of San Francisco, offers an exceptional Contemporary American dining experience. This eclectic bar and restaurant skillfully merges regional American cuisine with a flair for the unconventional, creating a menu that delights and surprises. Reviewers rave about the “unique and flavorful” dishes, highlighting the perfectly cooked burgers and tender braised short ribs. The atmosphere is enriched by “awesome cocktails and food,” along with live music that elevates the dining experience. With excellent service and a seamless connection to the neighboring venue, The Chapel, Curio ensures a memorable night filled with culinary and cultural pleasures.

A photo of House of Prime Rib restaurant

2. House of Prime Rib

4.8

Exceptional(16169)

$$$$Price: Very Expensive

• Southern american • Civic Center / Hayes Valley / Van Ness

Booked 262 times today

House of Prime Rib in San Francisco is a beacon of authentic American cuisine, renowned for its "iconic" status and exceptional prime rib. With 62 years of unwavering dedication, it’s no surprise that this establishment garners glowing praise from loyal patrons who rave about its "festive" atmosphere and "superb" service. Guests continually highlight the "delicious" prime rib, which is described as "massive" and "perfectly cooked," making every visit a memorable experience. The lively ambiance and the meticulous attention from the staff ensure that every meal feels like a special occasion. Truly, House of Prime Rib offers a quintessential American dining experience.

A photo of Tartine Manufactory - San Francisco restaurant

3. Tartine Manufactory - San Francisco

4.8

Exceptional(1054)

$$$$Price: Expensive

• Southern american • Mission District

Booked 35 times today

Tartine Manufactory in San Francisco’s vibrant Mission District is a beacon of authentic American cuisine, celebrated for its mastery of artisanal bread and world-class sourdough pizza. Diners rave about the restaurant’s "outstanding" food and "fantastic" service, emphasizing the quality of its market-driven, seasonal menu. The pizzas, described as "some of the best in the city," showcase a true American culinary flair with unique toppings and a perfect crust. The atmosphere is equally inviting, with a "lovely, airy space" and a laid-back vibe that makes every visit a special occasion. Tartine Manufactory is a must-visit for anyone craving genuine American flavors.

4. Frances

4.8

Exceptional(3709)

$$$$Price: Very Expensive

• Southern american • The Castro

Booked 22 times today

Frances, nestled in the heart of The Castro in San Francisco, is a beacon of Contemporary American cuisine, celebrated for its vibrant and innovative dishes. Chef Melissa Perello’s seasonal menu masterfully showcases "California Cuisine," emphasizing fresh, locally sourced ingredients that "speak for themselves." Diners rave about the "phenomenal" short rib and "divine" house sourdough, noting the harmonious blend of flavors that elevate each dish. The restaurant’s ambiance is described as cozy yet elegant, making it a perfect spot for special occasions. With its "exemplary" service and carefully curated wine pairings, Frances offers an unforgettable dining experience that keeps patrons returning for more.

5. Mr. Digby's

4.7

Exceptional(494)

$$$$Price: Expensive

• Southern american • Noe Valley

Booked 30 times today

Mr. Digby's in Noe Valley, SF, is a standout for its exceptional Cocktail Bar experience, offering inventive and classic cocktails that delight patrons with every sip. Guests rave about the "Garden Gimlet" and "Dímelo," highlighting the creativity and precision in their drink menu. The bar's ambiance is warm and inviting, perfect for enjoying their "amazing, creative cocktails" in a cozy, polished setting. Whether you're stopping by for a quick drink or a leisurely evening, the friendly and skilled bartenders ensure an unforgettable experience. This neighborhood gem is not only about great drinks but also about fostering a welcoming community atmosphere.

A photo of State Bird Provisions restaurant

6. State Bird Provisions

4.7

Exceptional(3408)

$$$$Price: Very Expensive

• Southern american • Western Addition

Booked 86 times today

State Bird Provisions in Western Addition, San Francisco, offers an extraordinary American dining experience that truly stands out. Known for its inventive "dim sum" style service, this restaurant presents a creative twist on classic American flavors. Diners rave about the "delicious, innovative, and surprising" small dishes that keep the experience fresh and exciting. With impeccable service and a lively atmosphere, patrons find themselves returning for more. The signature quail dish and the adventurous blue corn-pepita pancakes with braised bacon and coffee butter are must-tries. As one enthusiastic diner put it, "Every dish was like culinary viagra," making this a must-visit for any American cuisine enthusiast.

7. The Progress

4.8

Exceptional(2584)

$$$$Price: Very Expensive

• Southern american • Western Addition

Booked 53 times today

The Progress in Western Addition, San Francisco, offers a truly remarkable Californian dining experience. Celebrated for its "innovative menu" and "delicious flavors," this restaurant uses entirely local ingredients to craft dishes that highlight the essence of Californian cuisine. Guests rave about the duck, described as a "must-try" and "100% juicy and tender," alongside other inventive dishes like the seaweed noodles and Tierra vegetables masa dumplings. The ambiance is "casual and playful," providing the perfect setting for what many reviewers describe as "the best meal in SF." With excellent service and a creative menu, The Progress is an unmissable culinary gem.

8. Starbelly

4.6

Exceptional(1633)

$$$$Price: Moderate

• Southern american • The Castro

Booked 42 times today

Starbelly in The Castro serves an exceptional Californian cuisine experience that has diners raving about its “consistently delicious food and cocktails” and “warm, helpful, and personable” service. This urban gem brings Californian comfort food to life with a seasonal menu that harmonizes perfectly with their craft cocktails, beer, and wine. Diners can enjoy dishes like the popular corn pizza and fresh pasta amidst a lively ambiance, often described as “an oasis in the heart of the city.” The charming garden patio adds a special touch, making Starbelly a vibrant neighborhood favorite perfect for any occasion.

A photo of The Palm Court at RH San Francisco restaurant

9. The Palm Court at RH San Francisco

4.8

Exceptional(1922)

$$$$Price: Very Expensive

• Southern american • Potrero Hill / Dogpatch

Booked 86 times today

The Palm Court is located in RH San Francisco's Gallery at the Historic Bethlehem Steel Building. Recalling the distinctive glamour of San Francisco's Gilded Age, the stunning statement space is sheathed in Italian Calacatta gold marble and features a cascading center fountain, towering Medjool date palms and glimmering chandeliers. Adjacent to the restaurant, two luminous wine bars offer exceptional wines and Champagnes from around the world.For group dining inquiries, please email: sfhospitality@rh.com

10. Wayfare Tavern

4.6

Exceptional(7949)

$$$$Price: Moderate

• Southern american • Financial District / Embarcadero

Booked 97 times today

Wayfare Tavern, nestled in San Francisco's bustling Financial District, stands as a beacon of exemplary Contemporary American cuisine. Chef Tyler Florence masterfully crafts dishes that transport diners to an era of authentic American flavors inspired by the early 20th century. The restaurant is celebrated for its "impeccably delicious" offerings, with standout dishes like the renowned "Mary’s Fried Chicken" and "deviled eggs" that leave patrons raving. The vibrant yet cozy Victorian ambiance complements the culinary delights, making it perfect for any occasion. With "phenomenal" service and a dedication to quality, Wayfare Tavern is a must-visit destination for food enthusiasts.

‘About the restaurant’ descriptions have been generated using an artificial intelligence model comprised of OpenTable proprietary data that has not been independently verified by OpenTable. The content is presented as-is, for informational purposes only.

See what locals rave about

From verified diners like you

C
Casey
Chicago / Illinois •7 reviews
5.0
Dined 6 days ago
The food was delicious, the service was outstanding and the wine was perfect! Every moment of our evening felt thoughtful and intentional. You could tell the staff were happy and having fun. A lovely night, excited to return!
More info
PreludePrice: Very Expensive• Californian• Financial District / Embarcadero
•
4.7
OT
OpenTable Diner
Chicago / Illinois •1 review
5.0
Dined 7 days ago
A little piece of New Orleans! Great food, drinks, service, and music.
More info
Biscuits and BluesPrice: Expensive• Southern• Downtown / Union Square
•
4.4
F
Fides
San Francisco Bay Area •44 reviews
5.0
Dined on May 24, 2025
Great neighborhood place. Food is excellent and servers are friendly. I will continue to bring friends and family here.
More info
Hard Knox Cafe on Clement StreetPrice: Moderate• Southern• Richmond District
•
4.6

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